Neuroendocrine Cancer-related Syndromes occur due when Neuroendocrine Cancer causes changes to the cell resulting in the abnormal production and excess release of specific peptides and / or hormones by Neuroendocrine Cancer cells –
for example Carcinoid Syndrome (Serotonin, Histamine & Kinins).
These syndromes occur in approximately 40% of all Neuroendocrine Tumours, rarely occurring in Neuroendocrine Carcinomas.
is associated with Neuroendocrine Tumours (NETs) that form in your pancreas or the upper part of your small intestine (duodenum). These tumors, called Gastrinomas, secrete large amounts of the hormone gastrin, which causes your stomach to produce too much acid. The excess acid then leads to peptic ulcers, as well as to diarrhoea and other symptoms, including acid reflux, heartburn, stomach/chest pain, diarrhoea and low haemoglobin (anaemia) causing tiredness.
is associated with Neuroendocrine Tumours (NETs) that form in your pancreas or the upper part of your small intestine (duodenum). These tumors, called Insulinomas, secrete large amounts of the hormone insulin, which causes your blood sugar levels to drop – sometimes quite severely. We need a certain blood sugar level to ensure our body (and all of it cells) has enough energy to function normally. When blood sugar levels drop too low, or too severely, this can lead to symptoms that may include dizziness, light-headedness, sweating, hunger, confusion & irritability. If the level drops too low or too severely this can even lead to coma / loss of consciousness. Symptoms often get better, are alleviated, by eating – so weight gain – sometimes to obese levels, rather than weight loss, can occur.
Clinical hypoglycaemia is proven through fasting blood tests, that are carried out in hospital, in order to be completed safely.
is associated with Neuroendocrine Tumours (NETs) that form in your pancreas. These tumors, called VIPomas, secrete large amounts of Vasoactive Intestinal Peptide (VIP). This peptide helps regulate gastrin, it works to neutralise stomach acid when food leaves the stomach and enters the small bowel – which helps with nutrient uptake, and promotes the secretion of water and electrolytes by the small and large intestines. It also works to ensure that food passes through the small and large intestines slowly enough for nutrients from food to be absorbed properly (a process known as transit time). Too much VIP can result in reduced levels of acid in the stomach. very watery, frequent and high-volume diarrhoea (up to or in excess of 3 litres a day), and severe changes in potassium levels in the blood (low potassium) – that may affect heart rate. Hospital admission may be required to deal with these symptoms – as severe symptoms can be life-threatening.
is associated with Neuroendocrine Tumours (NETs) that form in your pancreas or the upper part of your small intestine (duodenum). These tumors, called Glucagonomas, secrete large amounts of the hormone glucagon, which can cause your blood sugar levels to rise above normal. Glucagon works along with the hormone insulin to control blood sugar levels and keep them within set levels. When glucagon levels rise too high, this can lead to Necrotising Migratory Erythema (NME) – a skin rash that can spread across the body that may look like eczema. Glucagonomas may also cause symptoms of diabetes, (like feeling tired, going pee a lot, dry mouth), nausea, weight loss and a low haemoglobin (anaemia). Diarrhoea, blood clots and other changes to skin, nails and hair may also occur.
Growth Hormone is usually produced and released from the pituitary gland and helps to regulate all cell growth. When growth hormone is over-produced, from any source, it can cause a condition called Acromegaly. Acromegaly usually affects middle-aged adults, though it can develop at any age. In children who are still growing, too much growth hormone can cause a condition called gigantism. Bones increase in size, including those of the hands, feet and face.
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ParaThyroid Hormone related Peptide – is usually associated with the parathyroid glands. Four small glands that sit close to the thyroid gland in the neck. They help to regulate normal calcium levels within the blood. Abnormal levels can cause symptoms of hyperparathyroidism – which can be mild, vague or severe – and include hypercalcaemia (high calcium levels), nausea, vomiting or loss of appetite, depression, confusion, agitation or forgetfulness, excessive urination, palpitations, abdominal pain, tiring easily or weakness and / or bone and joint pain.
AdrenoCorticoTropic Hormone plays a part in how the body responds to stress. ACTH is produced in the pituitary gland and stimulates the production and release of cortisol from the adrenal gland. In health, cortisol helps the body respond to stress by maintaining blood pressure and heart function, keeping the immune system in check and by converting fat, carbohydrates, and proteins into energy. Too much cortisol can lead a condition called Cushing’s Syndrome – symptoms include muscle weakness, weight loss, hypertension (high blood pressure), excessive hair growth, and osteoporosis, hypokalaemia (low potassium levels) and hyperglycaemia (raised blood sugars).
Calcitonin is produced in the thyroid gland and is involved in helping to regulate levels of calcium and phosphate in the blood, balancing out the effects of parathyroid hormone.
Too much calcitonin can lead to watery diarrhoea and facial flushing, may also lead to Hypercalcaemia (raised calcium). nausea, vomiting or loss of appetite, depression, confusion, agitation or forgetfulness, excessive urination, palpitations, abdominal pain, tiring easily or weakness and / or bone and joint pain.
Neurotensin is produced in the lower end of the small bowel and helps to regulate how the small bowel works. It also plays a role in gastric acid production. There is no syndrome associated with neurotensin alone, but symptoms may occur if it is secreted alongside VIP and / or Gastrin – and may lead to symptoms that include low blood pressure /hypotension, flushing, diarrhoea, unintended weight loss, and diabetes.
Pancreatic Polypeptide – rarely produces syndrome. But may be secreted alongside VIP and / or Gastrin. It may play a role in smooth muscle contraction and is thought to be what causes the gallbladder to squeeze and release bile into the digestive system when we eat.
Somatostatin is a hormone that is produced in several parts of the body including the pancreas and gut (digestive system) – it helps to regulate the production and release of several other hormones. Given its effect on the digestive system and in particular gut hormones and peptides, too much can result in symptoms that may include diabetes mellitus, formation of gallstones, intolerance to fat in the diet and diarrhoea.
Note: Chemically similar equivalents of somatostatin (somatostatin analogues) are often used as a medical therapy to control excess hormone secretion in patients with Neuroendocrine Cancer-related Syndromes.