Pre treatment test for those due to receive Fluoropyrimidine- based chemotherapy (5-fluorouracil, capecitabine and tegafur)
NHS Patients to be offered a rapid DPD deficiency test to help decide whether to go ahead with treatment, opt for a lower dose or use a different method of tackling tumours.
While most patients undergoing chemotherapy do not suffer severe side effects a small number taking certain drugs called fluoropyrimidines (5-FU and capecitabine) can suffer nausea, vomiting, diarrhoea, breathlessness and severe skin reactions and, in rare cases, the reaction can be life-threatening.
The blood test detects a particular form of a gene which means that someone is less able to break down chemotherapy drugs in their body.
As many as 40% of those who get tested are expected to benefit from starting on a lower dose or have a different treatment altogether.
You can read the Clinical Commissioning Urgent Policy Statement published November 2020 – here.